Landmark Pharma
Landmark Pharma
CBD Belapur, Mumbai, Maharashtra
GST No. 27AAHFL5309G1ZC
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Anti Cancer Capsuls

Prominent & Leading Exporter from Mumbai, we offer tacrolimus capsule and tacrograf capsules.

Tacrolimus Capsule

Tacrolimus Capsule
  • Tacrolimus Capsule
  • Tacrolimus Capsule
  • Tacrolimus Capsule
  • Tacrolimus Capsule
  • Tacrolimus Capsule
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Product Details:

CompositionTacrolimus Capsules
Packaging TypeStrip
Packaging Size10 Capsules
BrandBiocon,Emcure,Panacea Biotec,Wockhardt Ltd,etc.
Usage/ApplicationPrevention of organ rejection in transplant patients

Indication:
indicated for organ transplant rejection prophylaxis. Patients are prescribed this medicine after an organ transplant, so as to help prevent the immune system from attacking the organ and to stop the body rejecting the transplant.


Mechanism of action:

Tacrolimus is a macrolide calcineurin inhibitor. In T-cells, activation of the T-cell receptor normally increases intracellular calcium, which acts via calmodulin to activate calcineurin. Calcineurin then dephosphorylates the transcription factor nuclear factor of activated T-cells (NF-AT), which moves to the nucleus of the T-cell and increases the activity of genes coding for IL-2 and related cytokines. Tacrolimus prevents the dephosphorylation of NF-AT. In detail, Tacrolimus reduces peptidyl-prolyl isomerase activity by binding to the immunophilin FKBP12 (FK506 binding protein) creating a new complex. This FKBP12-FK506 complex interacts with and inhibits calcineurin, thus inhibiting both T-lymphocyte signal transduction and IL-2 transcription. Although this activity is similar to that of ciclosporin, the incidence of acute rejection is reduced by tacrolimus use over ciclosporin. Although short-term immunosuppression concerning patient and graft survival is found to be similar between the two drugs, tacrolimus results in a more favorable lipid profile, and this may have important long-term implications given the prognostic influence of rejection on graft survival.


Dosage and Administration:

Oral tacrolimus is taken twice daily. Starting doses range between 0.075 mg/kg/day to 0.2 mg/kg/day. Doses vary widely and are based on tests that measure the amount of tacrolimus in the blood. Taking tacrolimus with food can reduce some of the abdominal pain that can occur with this medicine; however, food can reduce the amount of tacrolimus that is absorbed. This is especially true with fatty foods. Capsules should be taken consistently with or without food in order to avoid major swings in blood levels. Grapefruit juice increases blood levels of tacrolimus and should be avoided. The injection is only used for patients who cannot tolerate tacrolimus capsules.

Side effects:
Tacrolimus is associated with many and various side effects. These include:· baldness,anemia,loss of appetite,diarrhea,high concentrations of potassium in the blood,high blood pressure, nausea, vomiting, ,tingling sensation in the extremities, itching, tremor, fever, headache, rash, high blood sugar concentrations, and, abdominal pain.

Precaution:
An overdose Tacrolimus Unlikely to threaten life, call an emergency room or a poison control center for advice if you suspect that a very large dose of Tacrolimus has been ingested.There are no restrictions on food, beverages, or activities while taking Tacrolimus otherwise directed by your physician.


Store:
Tacrolimus is usually handled and stored by a health care provider. If you are using tacrolimus at home, store tacrolimus as directed by your pharmacist or health care provider. Keep tacrolimus out of the reach of children and away from pets.

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Tacrograf Capsules

Tacrograf Capsules
  • Tacrograf Capsules
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Product Details:

CompositionTacrograf Capsules
Packaging TypePacket
Packaging Size5X10 Capsules
BrandBiocon

Tacrograf (Tacrolimus) belongs to a group of medicines known as immunosuppressive agents. It is used to lower the body's natural immunity in patients who receive kidney transplants. When a patient receives an organ transplant the body's defense cells will try to reject the transplanted organ.
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Kumar Rupesh (CEO)
Landmark Pharma
215, A Wing, Shiv Chamber, Plot No. 21, Sector 11, CBD, Belapur
Mumbai - 400614, Maharashtra, India


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